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The film was met with negative reviews from critics, but became somewhat of a box office success.
The same year Saldana starred in the comedy-drama Drumline (2002), alongside Nick Cannon, which was met with generally favorable reviews.
She again reprised the role in the sequel Avengers: Infinity War (2018), and in an untitled fourth Avengers film, which is scheduled to be released in 2019. Mollé in I Kill Giants, Anders Walter's adaptation of Joe Kelly's graphic novel I Kill Giants. In July 2016, during an interview with Net-a-Porter's The Edit, Saldana revealed that she has Hashimoto's thyroiditis, an autoimmune disease, along with her mother and sisters.
To combat the effects of this disease, Saldana said she and her husband adhere to a gluten- and dairy-free diet.
Concurrently, she performed with the New York Youth Theater; her appearance in their production of Joseph and the Amazing Technicolor Dreamcoat led a talent agency to recruit her.
Her previous dance training, and her acting experience, helped her land her first film role, playing talented and headstrong ballet student Eva Rodriguez in Center Stage (2000).
Saldana's second high-profile film in 2009 was James Cameron's Avatar, in which she starred as the alien hunter Neytiri.
Saldana's first film role was in Center Stage (2000), directed by Nicholas Hytner, about a group of young dancers from various backgrounds who enroll at the fictitious American Ballet Academy in New York City.
She then appeared in the Britney Spears vehicle Crossroads (2002).
In Pirates of the Caribbean: The Curse of the Black Pearl (2003), she played Anamaria, a female pirate who signs up to join Will Turner and Mr.
Gibbs for a chance to confront Jack Sparrow for stealing her ship.